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Year : 2011  |  Volume : 9  |  Issue : 5  |  Page : 325-329

Antimicrobial activity of Stevioside on periodontal pathogens and Candida Albicans - An invitro study

1 Department of Community Dentistry, College of Dental Sciences, Davangere. Karnataka-577 004, India
2 Kle University's College of Pharmacy, Vidyanagar, Hubli- 580 031, Karnataka, India

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Background: A number of oral diseases and disorders have been associated with diabetes mellitus and periodontitis has been identified as a possible risk factor for poor metabolic control in subjects with diabetes. The presence of Candida species and the density of candidal growth in the oral cavity is often said to be increased in patients with diabetes mellitus. Stevia is a new crop in that is gaining very high popularity amongst all type of sweetener users as most ideal substitute for sugar. Possessing antimicrobial property thus gives an added benefit. Objective: To evaluate the in vitro antimicrobial activity of stevioside on Candida albicans, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and to assess the minimal inhibitory concentrations of stevioside extract against the three organisms. Methodology: Pure powder of Stevioside, glycoside extracted from Stevia rebaudiana , was obtained. 100% pure solutions of stevioside was prepared by mixing well the appropriate amount of stevioside with an inert solvent di methyl sulfoxide (negative control). The antimicrobial efficacy was assessed using agar well technique. The minimal inhibitory concentration was assessed using serial tube dilution technique. Results: At the end of 48 hours, stevioside showed statistically significant antimicrobial activity against all the three micro organisms tested in comparison to the control. The zone of inhibition demonstrated against C. albicans was maximum. Conclusion: This study points to the probable antimicrobial effect of stevioside against C. albicans, P. gingivalis and A. actinomycetemcomitans. The antidiabetic property of stevioside coupled with the demonstrated antimicrobial property can lead to cheap and readily available natural drugs for the control of diabetes, periodontal disease and candidiasis.

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