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Year : 2011  |  Volume : 9  |  Issue : 5  |  Page : 319-324

Antimicrobial activity of antidiabetic herbs on Porphynomonas Gingivalis, Aggregatibacter Actinomycetemcomitans and Candida Albicans - An invitro study

1 Department of Community Dentistry, College of Dental Sciences, Davangere. Karnataka-577 004, India
2 Department of Pharmacognosy, Shree Dhanvantary Pharmacy College, Near Railway Station, Kim- 394 110, Surat, Gujarat, India

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Background: A number of oral diseases and disorders have been associated with diabetes mellitus and periodontitis has been identified as a possible risk factor for poor metabolic control in subjects with diabetes. The presence of Candida species and the density of candidal growth in the oral cavity is often said to be increased in patients with diabetes mellitus. Various herbs possess anti diabetic property. Possessing antimicrobial property thus gives an added benefit. Objective: To evaluate the in vitro antimicrobial activity of Gymnema sylvestre (madhunashini), Azadirachta indica (neem), Piper longum (long pepper) and Cinnamomum tamala (Indian bay leaf) on Candida albicans, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans and to assess the minimal inhibitory concentrations of the extracts against the three microorganisms. Methodology: All the herbs were dried and powdered. Solvent extracts were obtained with methanol by maceration followed by filtration and evaporation. The antimicrobial efficacy was assessed using agar well technique. The minimal inhibitory concentration was assessed using serial tube dilution technique. Results: Neem showed the highest antifungal activity against C. albicans, followed by madhunashini, bay leaf and long pepper. Only madhunashini showed antimicrobial activity against P. gingivalis. Neem showed the highest antibacterial activity against A. actinomycetemcomitans, followed by madhunashini. Conclusion: This study points to the probable antimicrobial effect of some solvent extracts of antidiabetic herbs against C. albicans, P. gingivalis and A. actinomycetemcomitans. The antidiabetic property of these herbs coupled with the demonstrated antimicrobial property can lead to cheap and readily available natural drugs for the control of diabetes and associated periodontal disease and candidiasis.

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