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Year : 2009  |  Volume : 7  |  Issue : 14  |  Page : 55-59

Salivary J1-Glucuronidase as a marker for chronic Periodontitis

Department of Periodontics, Meenakshi Ammal Dental College, Chennai, India

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Aim: This study was conducted to correlate the relationship between J3-glucuronidase activity in whole saliva with severity of periodontal disease. Methodology: The study population consisted of 20 subjects (14 males and 6 females), selected from the out patient department of periodontics, Meenak:shi Ammal Dental College and Hospital, Chennai. A sample of unstimulated whole saliva and a venous blood sample were obtained from each subject, and a periodontal examination, which included measurement of pocket depth, attachment level, and gingival index was performed. The unmodified saliva samples were frozen at - 20°C and analyzed for -glucuronidase activity. The blood samples were analyzed for number of total leukocytes, neutrophils, lymphocytes and monocytes. Results: A significant positive relationship was found between increase J3-glucuronidase activity with increase pocket depth and attachment loss. In addition a significant correlation existed between neutrophil count and -glucuronidase activity. Conclusion: The results suggest that a significant association between periodontal clinical parameters and salivary J3-glucuronidase activity. Due to non-invasive and simple nature of saliva collection when compared to GCF, estimating the level of the enzyme, -glucuronidase in whole saliva might be used as a marker to assess the severity of periodontitis, and a means of monitoring the response to treatment.

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